The ESA/OXA metabolites refer to two compounds associated with exposure to organophosphorus pesticides, specifically ethylphosphoric acid esters (ESA) and oxonic esters (OXA). These metabolites are produced during the breakdown of organophosphorus pesticides in the human body. Organophosphorus pesticides, commonly used in agriculture, pose health risks. ESA/OXA metabolites, formed during detoxification in the body, are detected in urine, serving as an exposure indicator. Some pesticides act on the nervous system. Monitoring ESA/OXA metabolites is crucial to assess human exposure to organophosphorus pesticides and understand potential health risks. Research continues to explore links between pesticide exposure and various health effects, while measures are taken to minimize excessive use of these chemicals and protect public health.